Regulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions.
نویسنده
چکیده
As its name implies, calcium/calmodulin-dependent protein kinase II (CaMKII) is calcium dependent. In its basal state, the activity of CaMKII is extremely low. Regulation of intracellular calcium levels allows the neuron to link activity with phosphorylation by CaMKII. This review will briefly summarize our current understanding of the intramolecular mechanisms of activity regulation and their modulation by Ca 2 /CaM and will then focus on the growing number of other modes of intermolecular regulation of CaMKII activity by substrate and scaffolding molecules.
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عنوان ژورنال:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
دوره 24 39 شماره
صفحات -
تاریخ انتشار 2004